motivated by curiosity.

Epiquinamide: A poison that wasn’t from a frog that was

02.06.09 Posted in Medicinal Chemistry by

In 2003, we reported the isolation, structure elucidation, and pharmacology of epiquinamide, a novel alkaloid isolated from an Ecuadoran poison frog, Epipedobates tricolor. Since then, several groups, including ours, have undertaken synthetic efforts to produce this compound, which appeared initially to be a novel, beta-2-selective nicotinic acetylcholine receptor agonist. Based on prior chiral GC analysis […]