motivated by curiosity.

Frequency-dependent representation of feedback-related information in the human medial and lateral prefrontal cortex

06.06.16 Posted in Human Neurophysiology Studies by

The feedback-related negativity (FRN) is a commonly observed potential in scalp electroencephalography (EEG) studies related to the valence of feedback about a subject’s performance. This potential classically manifests as a negative deflection in medial frontocentral EEG contacts following negative feedback. Recent work has shown prominence of theta power in the spectral composition of the FRN, […]

Studying task-related activity of individual neurons in the human brain

02.17.13 Posted in Human Neurophysiology Studies by

Single neuronal studies remain the gold standard for studying brain function. Here, we describe a protocol for studying task-related single neuronal activity in human subjects during neurosurgical procedures involving microelectrode recordings. This protocol has two phases: a pre-operative and intra-operative phase. During the pre-operative phase we discuss informed consent, equipment setup, and behavioral testing. During […]

Encoding of rules by neurons in the human dorsolateral prefrontal cortex

11.21.12 Posted in Human Neurophysiology Studies by

We use rules to extend learned behavior beyond specific instances to general scenarios. The prefrontal cortex (PFC) is thought to play an important role in representing rules, as evidenced by subjects who have difficulty in following rules after PFC damage and by animal studies demonstrating rule sensitivity of individual PFC neurons. How rules are instantiated […]

Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation

05.17.12 Posted in Human Neurophysiology Studies by

The ability to optimize behavioural performance when confronted with continuously evolving environmental demands is a key element of human cognition. The dorsal anterior cingulate cortex (dACC), which lies on the medial surface of the frontal lobes, is important in regulating cognitive control. Hypotheses about its function include guiding reward-based decision making, monitoring for conflict between […]

Single-neuron responses in the human nucleus accumbens during a financial decision-making task

04.06.12 Posted in Human Neurophysiology Studies by

Linking values to actions and evaluating expectations relative to outcomes are both central to reinforcement learning and are thought to underlie financial decision-making. However, neurophysiology studies of these processes in humans remain limited. Here, we recorded the activity of single human nucleus accumbens neurons while subjects performed a gambling task. We show that the nucleus […]