three sigma.

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Human

Single Neuronal and Intermittent Stimulation Studies of Cognition
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About:
We have developed methods and tools for conducting cognitive tasks while recording single neuronal activity in patients undergoing deep brain stimulation surgery. This technique allows for unprecedented access to understanding how human beings encode information for abstract cognitive processes, such as: applying rules, decision-making, reward processing, and error monitoring. In addition, we are exploring new neuromodulation techniques to understand the effects of intermittent stimulation on cognitive and motor processes.
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Monkey

Single Neuronal and Intermittent Stimulation Studies of Learning and Memory
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We have developed tools for performing simultaneous multi-site cortical and subcortical recordings in non-human primates. Specifically, we are interested in exploring the role of the ascending cholinergic system arising from the basal forebrain in learning and memory. The interaction of the nucleus basalis with cortical regions and the medial septal nucleus with the hippocampus is the focus of current experiments. In addition to this, we are exploring closed-loop methods guided by our neurophysiological findings to modulate learning and memory systems.
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Education

Intersection of Technology, Neurophysiology, and Education
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About:
For many years, education and neuroscience -- although fundamentally intertwined -- have been developing largely in parallel. In recent years, with the advancement of technology and enterprise the potential for education to be guided by neuroscience is greater than ever. We are working to understand these core intricacies and develop methods and applications for producing platforms to effectively educate large audiences. In addition, we are actively working to devise novel empirical methods to further understand the convergence of neuroscience and education.
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Technology

Open Source Neurophysiology Tools
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About:
Technologies such as computer-aided design, 3-d printing, and micro-controllers have recently become widely available and low-cost. We are working to develop open source tools that will provide innovative low-cost high quality instruments to aid in neuroscience research. Our projects include: optical rodent tracking, an automated plus-maze, and a modular acute microdrive system.